Overview
Repurposing biology
The Steinmetz Lab’s mission is to push to new frontiers in human and plant health through design, development and testing of materials and biologics derived from plant viruses. Our vision is the translation of promising candidates into clinical and commercial applications. Our approach is to redesign and repurpose naturally occurring nanoparticles derived from plant viruses.
Next-generation nanotechnology depends upon the capacity to precisely alter size and shape of nanostructured features with temporal and spatial control. In medicine and biology, phenomena happen at the nanoscale - hence nanoscale materials are particularly well suited to engage and interface with living systems. Plant viruses can be regarded as nature's nanomaterials - evolved to assemble with atomic precision to package and deliver cargo. While mammalian viruses have made headway in medicine, plant viruses offer advantages such as production in edible plants, high degree of stability (not requiring ultra-low freezers), and impeccable engineering design space. Through synthetic biology and chemical programming and assembly, plant viruses can be repurposed with new functionalities. We have developed a library of plant virus-based nanoparticles and through structure-function studies we are beginning to understand how to tailor these nanomaterials appropriately for human health and plant health.
Research is organized into several interconnected research thrusts:
Human health
- Plant viral drug and gene delivery.
- Vaccines and immunotherapies.
Precision farming
- Agricultural nanotechnology to increase food security.
- Next-generation engineered living materials (ELMs) for diverse applications.
Please also see our Center for Nano-ImmunoEngineering, Center for Engineering in Cancer, and UC San Diego Materials Research and Engineering Center.
Molecular farming of plant virus-based nanoparticles
Vaccines and Immunotherapy
Plant virus cancer immunotherapy. We demonstrated that nanoparticlesfrom a harmless plant virus, namely Cowpea mosaic virus (CPMV) stimulate apotent antitumor immune response in mouse models of melanoma, ovarian cancer,breast cancer, colon cancer and glioma. When thesenanoparticles are used as cancer immunotherapy and applied by intratumoralinjection, systemic and durable anti-tumor efficacy is achieved withimmunological memory to prevent metastatic disease and/or recurrence . Ongoing trials in companiondogs with melanoma indicate that the potent antitumor efficacy of the plantvirus-derived nanoparticles can be replicated in these animals . It isimportant to understand that the nanoparticle-stimulated immune-mediatedanti-tumor response is not limited totreatment of the identified, injectable tumor; our data indicate that the treatmentinduces a systemic, immune-mediated anti-tumor response against unrecognizedmetastases and protect patients from recurrence of the disease.
Drug delivery targeting human health
Molecular imaging and theranostics
Precision farming and agricultural nanotechnology
Engineered Living Materials
This research is carried out under our UC San Diego Materials Research Science and Engineering Center (MRSEC). We seek to develop methods to integrate engineered living matter, cells and plants, with polymeric materials. In doing so, we will create new composite materials that are responsive to diverse stimuli and capable of generating complex, genetically encoded material outputs. Our long-term research goals are to develop techniques that will enable the creation of materials at the living/non-living interface, with the potential for use in biosynthetic electronics, chemical threat decontamination, therapeutic synthesis/delivery, and soft robotics, among other applications.
Find out more here: https://mrsec.ucsd.edu/living-materials